Endocrine Abstracts

Background: Polycystic ovarian syndrome (PCOS) is a common reproductive-endocrine disorder seen in women; characterized by increased GnRH pulsatility, hyperandrogenism, and cyst formation in ovary. GnRH release is controlled by higher centres of brain namely, hypothalamus and pituitary through various feedback mechanisms, one of them being neurotransmitters. However, no clear data is available with respect to GnRH regulation by neurotransmitters in PCOS. The aim of the present...

Background and aim: polycystic ovarian syndrome is a multi aetiological female endocrinopathy wherein one of the major target organs affected is adrenal. It is important to note that adrenal plays key role in evoking stress mediated responses in brain; which can in turn affect GnRH, the main regulator of HPG axis. Along with corticotrophin releasing factor (CRF), newly discovered neuropeptides- urocortin2 and RF-amide related peptide-3 (RFRP-3) (mammalian GnIH analogue) are al...

Background and aim: Polycystic ovary syndrome (PCOS), the most common endocrine disorder in women of reproductive age with an estimated prevalence of 5–10%, is one of the most common causes of female infertility. The therapeutic options for PCOS are limited. Thereby, traditional knowledge of Ayurveda has been exploited to identify an herbal therapeutic target for PCOS. Pharmacokinetic (PK) studies on bioactive constituents of herbal drugs provide valuable information on b...

Background: Aloe vera gel has been proven to have hypoglycaemic, hypolipidemic, and steroid enzyme regulating properties. These are of clinical significance in reproductive pathology namely polycystic ovary syndrome (PCOS). Preliminary, ‘in-vitro’ studies suggested that non-polar component is responsible for the steroid enzyme modulating effect. This study investigates the role of non polar phytocomponent’s of aloe vera gel, which could be responsible i...